Effects of quetiapine on the brain-derived neurotrophic factor expression in the hippocampus and neocortex of rats.
نویسندگان
چکیده
The effects of antipsychotics on the brain-derived neurotrophic factor (BDNF) expression have been controversial. This study aimed to investigate the effects of chronic quetiapine administration on the BDNF mRNA expression in hippocampus and neocortex of rats with or without immobilization stress. The chronic administration (21 days) of quetiapine (10 mg/kg) significantly attenuated the decreased BDNF mRNA expression in the both hippocampal and cortical regions of rats caused by immobilization stress, and significantly increased the BDNF mRNA expression in the dentate gyrus of rats even without the immobilization stress. These results could add some theoretical bases to explain why quetiapine may improve cognitive symptoms of schizophrenia by stimulating BDNF mRNA expression.
منابع مشابه
Differential Effects of Resveratrol on the Expression of Brain-Derived Neurotrophic Factor Transcripts and Protein in the Hippocampus of Rat Brain
Background: The induction of brain-derived neurotrophic factor (BDNF) expression in the hippocampus has shown to play a role in the beneficial effects of resveratrol (RSV) on the learning and memory. The BDNF gene has a complicated structure with eight 5’ noncoding exons (I-IXa), each of which can splice to a common coding exon (IX) to form a functional transcript. Estrogens increase levels of ...
متن کاملThe Pattern of Brain-Derived Neurotrophic Factor Gene Expression in the Hippocampus of Diabetic Rats
Objective(s) The aim of this study was to evaluate the effects of regular exercise in preventing diabetes complication in the hippocampus of streptozotocin (STZ)-induced diabetic rat. Materials and Methods A total of 48 male wistar rats were divided into four groups (control, control exercise, diabetic and diabetic exercise). Diabetes was induced by injection of single dose of STZ. Exercise ...
متن کاملEffect of Endurance Training on Brain Derived Neurotrophic Factor (BDNF) and Tyrosine Kinase B (Trkb) Level in Hippocampus of Ischemic Induced Male Rats
Introduction: Brain derived neurotrophic factor (BDNF) have neuroprotective effect through binding with tyrosine kinase B (TrkB). Thus the Aim of the present study was to investigate the effects of eight weeks endurance training on BDNF and TrkB levels in the hippocampus of ischemic induced male rats. Methods: 40 Male wistar rats (12 weeks old and 228.19±21.18g) were divided into four groups, i...
متن کاملTHE EFFECT OF ENDURANCE TRAINING ON GENE EXPRESSION OF NERVE AND FIBROBLAST GROWTH FACTORS IN THE HIPPOCAMPUS OF RATS AFTER BRAIN STROKE
Background & Aims: Neurotrophic and growth factors are known to have positive effects on neuronal proliferation. However, findings on the effects of exercise training on these factors following brain stroke are limited. Thus, the aim of the present study was to investigate the effect of endurance training on gene expression of nerve growth factor (NGF) and fibroblast growth factor (FGF) in the ...
متن کاملThe effect of eight weeks of aerobic training and Ritalin on hippocampus Brain-derived neurotrophic factor in hyperactive rats
Introduction: Recently increased an expansion of interest in non-pharmacological interventions for attention-deficit/hyperactivity disorder. The aim of this study to investigate the effect of eight weeks of aerobic training and Ritalin on hippocampus Brain-derived neurotrophic factor in hyperactive rats. Methods: To implementation of this experimental research, 33 Wistar rats (weigh, 180-220g)...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Neuroscience letters
دوره 402 1-2 شماره
صفحات -
تاریخ انتشار 2006